IGV-001 – Glioblastoma
Glioblastoma multiforme (glioblastoma, or GBM) is a brain cancer that is nearly always fatal. It is the most common malignant tumor that affects the central nervous system (CNS) and overall the third most common tumor of the brain and CNS.
A person newly diagnosed with GBM has a median overall survival (OS) or life expectancy of 12 to 15 months, and less than 6% of GBM patients survive to five years after diagnosis.1 The current standard of care treatment is based on surgery to remove as much of the tumor as possible. Surgery is typically followed by radiotherapy and chemotherapy.
IGV-001 is Imvax’s most advanced product candidate, in development to treat GBM. It has completed a Phase 1a study in recurrent glioblastoma and a Phase 1b study in newly diagnosed glioblastoma which in total dosed 46 patients. In the Phase 1b study, IGV-001 was well tolerated and multiple efficacy signals were observed. These included significant improvements in progression-free survival2, radiographic evidence of tumor response, and multiple biomarkers changes that supported the presence of an immune response.
A randomized, placebo-controlled Phase 2b trial of IGV-001 in patients with newly diagnosed glioblastoma will be initiated in the near future.
IHV-001 – Hepatocellular Carcinoma (HCC)
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. It is estimated that approximately 42,000 new cases will be diagnosed in the U.S. in 2021 per the American Cancer Society.
The five-year survival rate for patients diagnosed with HCC is about 20%.3
Imvax is developing IHV-001 for the treatment of HCC. Preclinical studies are ongoing.
IOV-001 – Ovarian Cancer
Ovarian cancer is the fifth most deadly cancer among women in the U.S. according to the American Cancer Society. The ACS estimates that approximately 22,000 women in the U.S. are diagnosed annually, and approximately 14,000 women died of the disease in the U.S. in 2020.
Based on recent data, the five-year survival rate for Stage III-IV ovarian cancer is 25%. 4
Imvax is developing IOV-001 for the treatment of ovarian cancer. Preclinical studies are ongoing.
IPV-001 – Pancreatic Cancer
Approximately 60,000 new cases of pancreatic cancer will be diagnosed in the U.S. in 2021 according to the American Cancer Society. Pancreatic cancer is the third leading cause of cancer-related deaths. The ACS estimates there will be 48,000 deaths from pancreatic cancer in the U.S. in 2021.
The five-year survival rate for pancreatic cancer is 5%.5
Imvax is developing IPV-001 for the treatment of pancreatic cancer. Preclinical studies are ongoing.
1 Ostrom et al. (2018): doi 10.1093/neuonc/noy131
2 Compared to historical controls. Andrews et al. (2021): doi 10.1158/1078-0432.CCR-20-3805
3 Lee et al. (2021): doi 10.1093/jnci/djab079
4 Matulonis et al. (2016): doi 10.1038/nrdp.2016.61
5 Hidalgo et al. (2015): doi 10.1016/j.pan.2014.10.001